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SAMe (S-Adenosyl-L-methionine Disulfate Tosylate)

Name: SAMe (S-Adenosyl-L-methionine Disulfate Tosylate)

Other Name: S-adenosyl-L-methionine, SAM-e

Specification: 95.0%~103%

CAS NO: 97540-22-2

Formula: C22H34N6O16S4

Molecular Weight: 766.78

Certification: Kosher, Halal, FSSC 22000


S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate is the disulfate salt of the stable p-toluene-sulfonate complex of S-Adenosyl-L-Methionine (SAMe), known for its chemopreventive properties. Within cells, SAMe disulfate p-toluene-sulfonate undergoes hydrolytic conversion to its active form, SAMe. Although the precise mechanism of action is not fully understood, SAMe has been shown to reduce experimental liver damage and prevent experimental hepatocarcinogenesis. Additionally, SAMe may lower mitochondrial cytochrome C release, inhibit caspase 3 activation and poly(ADP-ribose) polymerase cleavage, and mitigate okadaic acid-induced hepatocyte apoptosis in a dose-dependent manner. SAMe is vital for cellular transmethylation reactions and is a precursor for polyamine and glutathione synthesis in the liver. A deficiency in SAMe is linked to chronic liver disease due to decreased activity of methionine adenosyltransferase 1A (MAT1A), the enzyme responsible for producing SAMe as the initial step in methionine catabolism.

S-Adenosyl-L-methionine disulfate tosylate is a derivative of the amino acid methionine. It is commonly used as a dietary supplement and in medical applications. Its supplementation can provide numerous health benefits, particularly in mental health, liver function, and joint health. However, it is essential to use it under medical supervision to avoid potential side effects and interactions with other medications. SAMe is involved in several important biochemical processes in the body, including the synthesis of neurotransmitters and the regulation of gene expression.

Main Function

Cognitive Function

SAMe has been shown to have cognitive-enhancing effects, including improved memory and attention.

Improve Depression

S Adenosyl l Methionine Tosylate has been shown to have antidepressant effects and is used as an alternative or adjunct therapy to prescription antidepressants.

Joint Health

SAMe has been shown to have anti-inflammatory properties and can help reduce joint pain and stiffness in conditions such as osteoarthritis.

Liver Health

S Adenosylmethionine Tosylate Disulfate plays a crucial role in liver function, including the metabolism of drugs and toxins. It has been shown to have hepatoprotective effects and can help protect the liver from damage caused by alcohol consumption, hepatitis, and other liver conditions. SAMe has been shown to have hepatoprotective effects and may be beneficial in the treatment of various liver diseases, including alcoholic liver disease, viral hepatitis, and non-alcoholic fatty liver disease.

Discover the Versatility of S-Adenosyl-L-Methionine-Tosylate Disulfate

S-Adenosyl-L-Methionine-Tosylate Disulfate, also known as "SAME disulfate tosylate" or "S-Adenosylmethionine tosylate disulfate," is a powerhouse ingredient that offers a multitude of uses and benefits. Let's delve into its remarkable applications:

1. Mood Support: 

SAME disulfate tosylate has been extensively studied for its positive effects on mood regulation. It serves as a natural mood enhancer, helping to alleviate symptoms of depression and promoting emotional well-being. Embrace a balanced and uplifted state of mind with SAME disulfate tosylate.

2. Liver Health: 

S-Adenosyl-L-Methionine-Tosylate Disulfate plays a crucial role in supporting liver function and promoting liver health. By facilitating the production of essential compounds necessary for detoxification, it contributes to overall liver well-being. Nurture your liver and unleash its natural detoxifying power.

3. Joint Comfort: 

Research suggests that SAME disulfate tosylate may offer significant benefits for joint health. Its anti-inflammatory properties can help reduce joint inflammation, support cartilage maintenance, and improve joint

S Adenosyl L Methionine Disulfate Tosylate Uses

1. Mood Support: 

SAME disulfate tosylate has gained recognition for its positive impact on mood regulation. Studies have shown that it can act as a natural mood enhancer, helping to alleviate symptoms of depression and promote emotional well-being. By supporting the production of essential neurotransmitters in the brain, it aids in maintaining a balanced and uplifted state of mind.

2. Liver Health: 

Your liver plays a vital role in detoxification and overall well-being. S-Adenosyl-L-Methionine Disulfate Tosylate actively supports liver function and promotes liver health. It aids in the production of vital compounds necessary for efficient detoxification processes, helping to safeguard the health of this essential organ.

3. Joint Comfort: 

If you're seeking relief from joint discomfort, SAME disulfate tosylate may be the answer. It possesses potent anti-inflammatory properties that can help reduce joint inflammation, support cartilage maintenance, and improve joint flexibility. By promoting joint comfort, it empowers you to embrace an active and fulfilling lifestyle.

4. Cognitive Function: 

Your brain health is of utmost importance, and SAME disulfate tosylate can contribute significantly to its optimization. It aids in the synthesis of neurotransmitters involved in cognitive function, such as serotonin, dopamine, and norepinephrine. By supporting healthy brain chemistry, it enhances focus, concentration, and overall mental acuity.

5. Cellular Health: 

S-Adenosyl-L-Methionine Disulfate Tosylate plays a critical role in numerous cellular processes. It participates in methylation reactions, which are vital for DNA and protein synthesis, neurotransmitter regulation, and overall cellular health. By providing the necessary methyl groups, it helps maintain the integrity and functionality of your cells.

6. Energy and Vitality: 

Feeling drained or lacking energy? SAME disulfate tosylate can assist in revitalizing your body. By contributing to the production of ATP (adenosine triphosphate), the primary energy currency of cells, it enhances your overall energy levels, supporting vitality and promoting a sense of well-being.

7. Support for Neurotransmitters: 

Neurotransmitters are crucial for proper communication between nerve cells. SAME disulfate tosylate aids in the synthesis and regulation of neurotransmitters, ensuring optimal transmission of signals throughout the nervous system. This, in turn, promotes healthy brain function and neurological well-being.

Harness the power of S-Adenosyl-L-Methionine Disulfate Tosylate and experience its broad spectrum of uses. As a leader in brain health solutions, Witspower is dedicated to providing you with the highest quality SAME disulfate tosylate to support your well-being. Trust us to deliver exceptional products that empower you to live a vibrant, fulfilling life.


Product NameSAMe (S-Adenosyl-L-methionine Disulfate Tosylate)
Physical PropertyS-Adenosyl-L-methionine Disulfate Tosylate95.0%~103%
Color and AppearanceWhite to off-white Powder
Loss on Drying≤3.0
Sulphated Ash≤0.5
SAM-e ION49.5~54.7%
S, S-Isomer≥75%
P-Toluenesulfonic Acid21.0%~24.0%
Sulfate (SO4)23.5%~26.5%
Related SubstancesS-adenosine-L-homocysteine≤1.0%
Total impurities≤3.5%
Heavy MetalsTotal ≤10ppm
MicrobiologicalTotal Plate Count≤1000cfu/g
Yeast &Mold≤100cfu/g


SAMe (S-Adenosyl-L-methionine Disulfate Tosylate)

Mood Support and Emotional Well-being:

SAMe has been extensively studied for its beneficial effects on mood regulation and emotional balance. It is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are essential for maintaining a healthy and stable mood. By supporting the production and availability of these neurotransmitters, SAMe promotes a positive outlook and overall emotional well-being.

Joint and Musculoskeletal Health:

S Adenosyl L Methionine Tosylate has shown promising results in supporting joint health and reducing discomfort associated with conditions such as osteoarthritis. It helps in the formation and repair of cartilage, the cushioning tissue between joints, and also supports the production of connective tissues, such as collagen. By promoting joint flexibility and reducing inflammation, SAMe aids in maintaining healthy joint function and mobility.

SAMe (S-Adenosyl-L-methionine Disulfate Tosylate)

Liver Function and Detoxification:

The liver is responsible for detoxifying harmful substances in the body. SAMe supports liver function by participating in essential biochemical processes involved in detoxification. It aids in the production of glutathione, a powerful antioxidant that helps neutralize toxins and protect liver cells from damage. By promoting liver health and aiding in detoxification, SAMe contributes to overall well-being.

Cognitive Function and Brain Health:

SAMe Disulfate Tosylate plays a vital role in maintaining optimal brain function and supporting cognitive processes. It is involved in the synthesis of phospholipids, which are essential components of brain cell membranes. By promoting the production and availability of these phospholipids, SAMe supports healthy brain structure and function, including memory, focus, and mental clarity.

SAMe (S-Adenosyl-L-methionine Disulfate Tosylate)

Cellular Health and Methylation Processes:

S-Adenosyl-L-Methionine-Tosylate Disulfate is a key methyl donor in the body, meaning it provides methyl groups for various biochemical reactions. Methylation is involved in DNA synthesis and repair, protein synthesis, neurotransmitter regulation, and many other vital processes. By supporting methylation reactions, SAMe contributes to overall cellular health, gene expression, and the proper functioning of various systems in the body.

Energy and Vitality:

S-Adenosyl-L-Methionine-Tosylate Disulfate is involved in the production of adenosine triphosphate (ATP), which is the primary energy currency of cells. Adequate levels of SAMe help ensure efficient ATP production, supporting optimal energy levels and overall vitality. By aiding in energy metabolism, SAMe plays a role in maintaining stamina and promoting a sense of well-being.

Logistics Tips

North America area:

Ship from LA warehouse

Other countries or areas:

Ship from China Production Base

Express by DHL or Fedex

Under 100kg, 4-6days

Door to door service, easy to pick up

By Air shipping

100KG-1000KG, 5-7 days

Airport to airport service, professional clearance broker needed.

By Sea shipping

Over 300KG, Around 30days

Port to port service, professional clearance broker needed.

SAMe (S-Adenosyl-L-methionine Disulfate Tosylate)

Our Service

SAMe (S-Adenosyl-L-methionine Disulfate Tosylate)

Our Services

1. Free sample is available for your evaluation

2. Outstanding quality assurance: COA, OU kosher certificate, Halal certificate, FSSC 22000 Quality Management Certificate, US-GRAS.

3. 30 days unconditional refund if unqualified.

4. 24 hours online to ensure timely responds.

Why Choose Witspower? Discover the Unmatched Advantages.

When it comes to sourcing the finest ingredients for brain health, Witspower is the name you can trust. We have built a reputation as a leading manufacturer, specializing in superior solutions for brain health in pharmaceuticals, nutraceuticals, and dietary supplements. Here's why choosing Witspower sets you on a path towards unparalleled success:

1. Unparalleled Purity: 

At Witspower, we believe in delivering nothing but the best. Our S-Adenosyl-L-Methionine-Tosylate Disulfate stands out for its exceptional purity, boasting a content level as high as 98%-99%. We adhere to stringent quality standards to ensure that our product surpasses your expectations, giving you the peace of mind you deserve.

2. Unwavering Focus on Brain Health: 

Witspower is not just any brand. We are driven by a passion for brain health, dedicating our efforts to addressing the unique challenges of senile diseases and memory improvement. With our S-Adenosyl-L-Methionine-Tosylate Disulfate, we offer you a comprehensive solution to enhance cognitive abilities and support brain health at its core.

3. Technological Advancements: 

We take pride in our innovative approach to manufacturing. While traditional methods rely on chemical processes, Witspower stands at the forefront of progress. We utilize cutting-edge microbial fermentation technology through biosynthesis synthesis, ensuring a sustainable and environmentally friendly production process. By choosing us, you align with our commitment to a greener future.

4. Robust Manufacturing Capacity: 

With a factory capacity of 1000 tons of Phosphatidylserine, Witspower possesses a strong manufacturing foundation. This allows us to fulfill orders promptly and meet the demands of our customers with ease. Our well-equipped facility empowers us to maintain consistency in delivering the highest quality S-Adenosyl-L-Methionine-Tosylate Disulfate to meet your needs.

5. Complete Third-Party Certification: 

We understand that your trust is earned, and we prioritize transparency. To provide you with the utmost confidence in our products, we have obtained comprehensive third-party qualification certifications. These certifications validate the quality, safety, and reliability of our S-Adenosyl-L-Methionine-Tosylate Disulfate, ensuring that you receive only the best.

6. Swift Delivery from the USA: 

We value your time and convenience. That's why we have established an overseas warehouse in the United States. With this strategic location, we can guarantee swift delivery of your orders within just 2 days. Experience the efficiency and reliability of Witspower as we bring our exceptional products straight to your doorstep.

Choose Witspower as your preferred partner, and together, we will unlock the tremendous potential of S-Adenosyl-L-Methionine-Tosylate Disulfate for brain health. With our commitment to excellence, technological innovation, and sustainable practices, we are poised to redefine the landscape of brain health products. Trust Witspower and embark on a journey towards enhanced cognitive well-being and a brighter future. Contact us today!

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